What is a Polynucleotide Treatment?
A Polynucleotide treatment, also known as PDRN-treatment or commonly referred to as the “salmon DNA treatment,” is an innovative skin-rejuvenating procedure that has been gaining popularity rapidly. And for good reason: this treatment delivers a powerful boost to the skin and results in a visibly fresher, smoother, and more radiant appearance.
If you struggle with fine lines, dull or tired-looking skin, or if you simply want to refresh and revitalize your complexion, this is the treatment for you. Polynucleotides work on a cellular level and stimulate the skin’s natural repair and regeneration processes.
The active ingredients are naturally occurring DNA building blocks derived from purified salmon extracts. They are clinically tested and have been safely used for years in both cosmetic and medical applications.
This treatment supports cell renewal, boosts collagen and elastin production, and improves skin microcirculation. The result? Firmer, smoother, and healthier-looking skin—even in delicate areas such as around the eyes.
Who is a PDNR-treatment suitable for?
The Polynucleotide treatment is suitable for nearly all skin types and is ideal for those looking to refresh, restore, or firm the skin.
This treatment is particularly effective for:
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Fine lines and early-stage wrinkles
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Dull or tired skin
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Skin laxity or loss of elasticity
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(Post-)acne and superficial scarring
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Dry or sensitive skin
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The delicate eye area needing extra firming
The Treatment Process
Your treatment begins with a thorough cleansing of the skin to remove makeup and impurities. This is followed by a gentle exfoliation to remove dead skin cells and prepare the skin for optimal absorption of the active ingredients. The salmon DNA (PDRN) is then applied using mesotherapy with Nanosoft needles or microneedling. Depending on your skin condition, we will determine during the treatment which application method suits your skin best.
During this process, tiny micro-channels are created in the skin, allowing the polynucleotides to penetrate more deeply. The treatment may feel slightly sensitive, but it is generally not painful.
Preparation
Before your appointment, it is helpful to come with clean skin. We will, of course, cleanse the skin again prior to treatment.
By using a polynucleotide (PDRN) serum at home, you can enhance and prolong the results. The Lumicen Boost Serum contains 3% PDRN combined with hyaluronic acid and is formulated as an intensive restorative serum for home use. This powerful serum supports cell renewal, improves skin texture, and increases both hydration and skin firmness.
Aftercare
After your Polynucleotide treatment, the skin may appear slightly red or feel sensitive, similar to a mild sunburn. This usually subsides within 24 to 48 hours.
Results After the PDRN-Treatment
You will notice visible improvement after just one session. The skin feels softer, smoother, and deeply hydrated. Your complexion appears fresher with a natural glow. Fine lines become less visible, and the overall skin texture becomes more even.
With repeated treatments, the skin quality improves progressively and structurally.
Pricing
Level 1: €145
Mesotherapy or microneedling with Polynucleotide around the eyes
Level 2: €160
Mesotherapy or microneedling with Polynucleotide around the eyes + intensive collagen and hyaluronic sheet mask
Level 3: €245
Mesotherapy or microneedling with Polynucleotide for the full face
Level 4: €265
Mesotherapy or microneedling with Polynucleotide for the full face + intensive collagen and hyaluronic sheet mask
Glass Skin Treatment in Amsterdam
Book an appointment or a free consultation at our Amsterdam IJburg location.
